Nanocrsytalisation of Active Pharmaceutical ingredients using Supercritical Fluid Technology

Lead Applicant: Dr Luis Padrela, Department of Chemical Sciences and Bernal Institute

Generating data on the nucleation and crystal growth and molecular dynamic modelling of the selected class of APIs during batch and continuous supercritical assisted crystallization methods for the generation of micro- and nanoparticles.

This project aims at contributing towards the ever-increasing need to develop novel nano/crystallization methods to produce micro- and nanoparticles of APIs with the desired physicochemical properties and polymorphic purity. Additonally, the project aims at developing computational modelling approaches which would allow rationalisation towards ultimately predicting the influence of distinct additives/polymers on the outcome of (nano)crystallization processes.